STRUCTURE-BASED VIRTUAL SCREENING AND CHARACTERIZATION OF A NOVEL IL-6 ANTAGONISTIC COMPOUND FROM SYNTHETIC COMPOUND DATABASE

Structure-based virtual screening and characterization of a novel IL-6 antagonistic compound from synthetic compound database

Jing Wang,1,* Chunxia Qiao,1,* He Xiao,1 Zhou Lin,1 Yan Li,1 Jiyan Zhang,1 Beifen Shen,1 Tinghuan Fu,2 Jiannan Feng1 1Department of Molecular Immunology, Beijing Institute of Basic Medical Sciences, 2First Affiliated Hospital of PLA General Hospital, Beijing, People’s Republic of China *These authors contributed equally to this work Abstract:

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Whole genome sequencing reveals a frameshift mutation and a large deletion in YY1AP1 in a girl with a panvascular artery disease

Abstract Background Rare diseases are pathologies that affect less than 1 in 2000 people.They are difficult to diagnose due to their low frequency and their often highly heterogeneous symptoms.Rare diseases have in general a high impact on the quality of life and life expectancy of patients, which are in general children or young people.The advent

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The larvicidal and non larvicidal histological effect of some aromatic plants on mosquito larvae Culex pipiens molestus) Diptera: Culicidae(

This study included laboratory ovulation of the effect of alcoholic(ethanol) extract of Teucrium polium, Peganum WILD SALMON-FORCE harmala,Thymus vulgaris and Physalis angulata.It was values LC50 (102.5,101.0,78.0 and 53.0 ppm) and LC90(130.0,128.0,136.0 and 80.0 ppm) for Teucrium polium,Peganum harmala,Thymus vulgaris and Physalis angulata respect

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Magnetoresistance in relativistic hydrodynamics without anomalies

Abstract We present expressions Digital Artwork for the magnetoconductivity and the magnetoresistance of a strongly interacting metal in 3 + 1 dimensions, derivable from relativistic hydrodynamics.Such an approach is suitable for ultraclean metals with emergent Lorentz invariance.When this relativistic fluid contains chiral anomalies, it is known t

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